Validating the Sensitivity and Performance of Near-Infrared Fluorescence Imaging and Tomography Devices Using a Novel Solid Phantom and Measurement Approach
Identifieur interne : 004915 ( Main/Exploration ); précédent : 004914; suivant : 004916Validating the Sensitivity and Performance of Near-Infrared Fluorescence Imaging and Tomography Devices Using a Novel Solid Phantom and Measurement Approach
Auteurs : B. Zhu [États-Unis] ; I.-C. Tan [États-Unis] ; J. C. Rasmussen [États-Unis] ; E. M. Sevick-Muraca [États-Unis]Source :
- Technology in cancer research & treatment : (Print) [ 1533-0346 ] ; 2012.
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- Pascal (Inist)
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Abstract
With the aid of indocyanine green (ICG), lymphatic architecture and function in both mice and humans has been successfully imaged non-invasively using near-infrared (NIR) fluorescence imaging devices. Maximal measurement sensitivity of NIR fluorescence imaging devices is needed for "first-in-humans" molecularly targeting NIR fluorescence agents that are brighter than non-specific ICG. In this study, we developed a solid phantom and measurement approach for the quantification of excitation light leakage and measurement sensitivity of NIR fluorescence imaging devices. The constructed solid phantom, consisting of quantum dots impregnated onto specularly reflective surface, shows long-term stability and can be used as a traceable fluorescence standard. With the constructed solid phantom, the intensified CCD (ICCD)-based device demonstrated more than 300% higher measurement sensitivity compared to the Electron Multiplying CCD (EMCCD) based device when integration time was maintained less than 1.0s.
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Zhu</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston</s1><s2>Houston, TX 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Tan, I C" sort="Tan, I C" uniqKey="Tan I" first="I.-C." last="Tan">I.-C. Tan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston</s1><s2>Houston, TX 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rasmussen, J C" sort="Rasmussen, J C" uniqKey="Rasmussen J" first="J. C." last="Rasmussen">J. C. Rasmussen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston</s1><s2>Houston, TX 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Sevick Muraca, E M" sort="Sevick Muraca, E M" uniqKey="Sevick Muraca E" first="E. M." last="Sevick-Muraca">E. M. Sevick-Muraca</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston</s1><s2>Houston, TX 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Technology in cancer research & treatment : (Print)</title><title level="j" type="abbreviated">Technol. cancer res. treat. : (Print)</title><idno type="ISSN">1533-0346</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Technology in cancer research & treatment : (Print)</title><title level="j" type="abbreviated">Technol. cancer res. treat. : (Print)</title><idno type="ISSN">1533-0346</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Fluorescence</term><term>Human</term><term>Lymphedema</term><term>Optical imaging</term><term>Performance evaluation</term><term>Sensitivity</term><term>Test object</term><term>Tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Sensibilité</term><term>Evaluation performance</term><term>Imagerie optique</term><term>Fluorescence</term><term>Tomographie</term><term>Lymphoedème</term><term>Cancérologie</term><term>Objet test</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">With the aid of indocyanine green (ICG), lymphatic architecture and function in both mice and humans has been successfully imaged non-invasively using near-infrared (NIR) fluorescence imaging devices. Maximal measurement sensitivity of NIR fluorescence imaging devices is needed for "first-in-humans" molecularly targeting NIR fluorescence agents that are brighter than non-specific ICG. In this study, we developed a solid phantom and measurement approach for the quantification of excitation light leakage and measurement sensitivity of NIR fluorescence imaging devices. The constructed solid phantom, consisting of quantum dots impregnated onto specularly reflective surface, shows long-term stability and can be used as a traceable fluorescence standard. With the constructed solid phantom, the intensified CCD (ICCD)-based device demonstrated more than 300% higher measurement sensitivity compared to the Electron Multiplying CCD (EMCCD) based device when integration time was maintained less than 1.0s.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Zhu, B" sort="Zhu, B" uniqKey="Zhu B" first="B." last="Zhu">B. Zhu</name></region><name sortKey="Rasmussen, J C" sort="Rasmussen, J C" uniqKey="Rasmussen J" first="J. C." last="Rasmussen">J. C. Rasmussen</name><name sortKey="Sevick Muraca, E M" sort="Sevick Muraca, E M" uniqKey="Sevick Muraca E" first="E. M." last="Sevick-Muraca">E. M. Sevick-Muraca</name><name sortKey="Tan, I C" sort="Tan, I C" uniqKey="Tan I" first="I.-C." last="Tan">I.-C. Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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